Association of inflammatory mediators and molecular markers of iron metabolism in pregnancies with pregestational obesity during the development of anemia: narrative review

Abstract

Obesity and anemia are major problems all over the world; pregnancies often suffer from these medical conditions. Obesity is associated with an increased risk of iron deficiency associated with the activation of inflammatory markers and their influence on iron regulatory pathways. All of the pregnant obese women have a mild inflammatory response, which later leads to increased hepcidin levels, thereby influencing iron metabolism. The purpose of this review was to summarize recent findings that have reported the measuring of markers of iron metabolism and inflammatory in pregestationally obese pregnancies in the development of anemia. This review examines obesity-related activation of inflammatory mediators as a potential primary cause