Correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma: A meta-analysis and trial sequential analysis.

IF 2 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Medical Biochemistry Pub Date : 2024-01-25 DOI:10.5937/jomb0-44538
Delin Wu, Yuna Liu, Yan Liu, Najuan Cui, Yan Zhu, Sidao Zheng, Shaohua Wang
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Abstract

Background: This study aims to uncover the potential correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma.

Methods: Literatures reporting the correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma published before 1st June, 2019 were searched in PubMed, Embase, Cochrane, Wanfang and CNKI. Eligible literatures were enrolled and their data were extracted. OR and its 95% CI were calculated for assessing the correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma. The included data were weighted by an inverse variance and then analyzed by a fixed or random effects model. Heterogeneity test and sensitivity analysis were performed on the enrolled reports. STATA12.1 and TSA (trial sequential analysis) were utilized for analyses.

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LTC4S -444 A>C 多态性与哮喘易感性之间的相关性:荟萃分析和试验序列分析
背景:本研究旨在揭示 LTC4S -444 A>C 多态性与哮喘易感性的潜在相关性:本研究旨在揭示LTC4S -444 A>C多态性与哮喘易感性之间的潜在相关性:方法:在PubMed、Embase、Cochrane、万方和CNKI中检索2019年6月1日之前发表的报道LTC4S -444 A>C多态性与哮喘易感性之间相关性的文献。对符合条件的文献进行了登记和数据提取。计算 OR 及其 95% CI,以评估 LTC4S -444 A>C 多态性与哮喘易感性之间的相关性。对纳入的数据进行反方差加权,然后采用固定或随机效应模型进行分析。对纳入的报告进行了异质性检验和敏感性分析。分析采用 STATA12.1 和 TSA(试验序列分析)。
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来源期刊
Journal of Medical Biochemistry
Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
3.00
自引率
12.00%
发文量
60
审稿时长
>12 weeks
期刊介绍: The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.
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