Assessment of fasting and postprandial lipid profile in diabetic patients and healthy individuals

Abstract

Background: Type II diabetes mellitus (DM) is characterized by insulin resistance such as glucose intolerance, dyslipidemia, and hypertension, and results in an increased predisposition to atherosclerotic vascular disease. The present study was conducted to evaluate fasting and postprandial lipid profile in diabetic patients. Materials & Methods: We put 80 type II diabetes patients in group I and 80 healthy subjects in group II. Parameters such as HbA1c, FBS, PBS, total cholesterol (TC), triglycerides (TG), high density lipoprotein – cholesterol (HDL-C), very-low-density lipoprotein cholesterol (VLDL) and low-density lipoprotein cholesterol (LDL) were determined. Results: Group I had 35 males and 45 females and group II had 40 males and 40 females. The mean VLDL was 35.3 mg/dl and 29.6 mg/dl, LDL was 174.4 mg/dl and 82.2 mg/dl, TG was 180.2 mg/dl and 154.3 mg/dl, TC was 210.8 mg/dl and 172.4 mg/dl, HDL-C was 46.2 mg/dl and 56.2 mg/dl, PBS was 142.2 mg/dl and 130.4 mg/dl and HbA1c was 9.2% and 4.6% in group I and II respectively. The difference was significant ( p <0.05). Conclusion: Postprandial lipid profile had higher values as compared to fasting lipid profile among type 2 DM patients.