Contribution of Particle Design Research to the Development of Patient-Centric Dosage Forms

IF 2.6 4区 材料科学 Q3 ENGINEERING, CHEMICAL KONA Powder and Particle Journal Pub Date : 2022-01-10 DOI:10.14356/kona.2022017
H. Takeuchi
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引用次数: 1

Abstract

A variety of dosage forms have been developed in order to achieve effective and safe drug delivery in topical or systemic drug administrations. In this review, formulation research and process issues related to a popular oral dosage form, the tablet, are introduced. Research on oral dosage forms, including orally disintegrating tablets (ODTs) and films (ODFs), which have recently been developed with an aim toward more patient-centric drug therapy, is also introduced. Another trend in recent drug therapy is an increase in the number of large bioactive molecules among the newly developed active pharmaceutical ingredients (APIs). To design dosage forms for these APIs, novel dosage form design and administration routes are required. For this purpose, we have tried to effectively use the polymer-coated liposomes in oral, pulmonary and ophthalmic administration. For example, suitable polymers were introduced for the design of specific administration routes, such as mucoadhesive liposomes for oral administration. The key point in these researches is the particle design for the component particles of final dosage forms, both in the case of coarse powder particle design for formulating solid dosage forms and in the case of colloidal particle design, such as the design of liposomes for peptide drug delivery.
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粒子设计研究对以病人为中心的剂型发展的贡献
为了在局部或全身给药中实现有效和安全的给药,已经开发了各种剂型。本文介绍了一种流行的口服剂型片剂的配方研究和工艺问题。本文还介绍了最近开发的以患者为中心的药物治疗为目标的口服剂型的研究,包括口腔崩解片(odt)和片(odf)。最近药物治疗的另一个趋势是新开发的活性药物成分(api)中大分子生物活性分子的数量增加。为了设计这些原料药的剂型,需要新颖的剂型设计和给药途径。为此,我们尝试将聚合物包被的脂质体有效地应用于口服、肺和眼给药。例如,适当的聚合物被引入到特定给药途径的设计中,如用于口服给药的黏附脂质体。这些研究的重点是最终剂型的成分颗粒的颗粒设计,无论是用于配制固体剂型的粗粉颗粒设计,还是用于多肽药物递送的脂质体等胶体颗粒设计。
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来源期刊
KONA Powder and Particle Journal
KONA Powder and Particle Journal 工程技术-材料科学:综合
CiteScore
8.40
自引率
4.90%
发文量
35
审稿时长
>12 weeks
期刊介绍: KONA publishes papers in the broad field of powder science and technology, ranging from fundamental principles to practical applications. Papers describing technological experience and critical reviews of existing knowledge in special areas are also welcome.
期刊最新文献
Editor’s Preface The 54th Symposium on Powder Technology and Special Lecture for the 30th Anniversary of the Establishment of HPTF The KONA Award 2021 General Information Effects of DEM Parameters and Operating Conditions on Particle Dynamics in a Laboratory Scale Rotating Disc
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