Molecular imaging of endocrine neoplasms with emphasis on 18F-DOPA PET: a practical approach for well-tailored imaging protocols.

The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... Pub Date : 2022-03-01 DOI:10.23736/S1824-4785.22.03450-1

Christelle Fargette, A. Imperiale, D. Taïeb

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引用次数: 2

Abstract

6-[18F]-L-fluoro-L-3, 4-dihydroxyphenylalanine (18F-DOPA) PET/CT can be a useful tool for the detection of different neuroendocrine tumors (NETs). The main determinants of 18F-DOPA uptake and retention by NETs are related to expression of LAT1/LAT2 transporters, expression and activity of AADC and biochemical phenotype, all being intimately inter-connected to their embryological origin. In order to improve sensitivity of 18F-DOPA PET, it is of main importance to perform indivisualized imaging protocols across primaries. This review provides a practical approach for performing well-tailored imaging protocols and describes the clinical value of the recommended radiopharmaceuticals.

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以18F-DOPA PET为重点的内分泌肿瘤分子成像:一种适合量身定制的成像方案的实用方法。

6-[18F]- l -氟- l - 3,4 -二羟基苯丙氨酸(18F- dopa) PET/CT可作为检测不同神经内分泌肿瘤(NETs)的有效工具。net吸收和保留18F-DOPA的主要决定因素与LAT1/LAT2转运蛋白的表达、AADC的表达和活性以及生化表型有关，所有这些都与其胚胎学起源密切相关。为了提高18F-DOPA PET的灵敏度，跨原色进行个性化成像方案是非常重要的。这篇综述提供了一种实用的方法来执行量身定制的成像方案，并描述了推荐的放射性药物的临床价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...

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