Phytochemical, antioxidant, and anti-inflammatory screening of the Egyptian Ulva lactuca methanolic extract

Records of Pharmaceutical and Biomedical Sciences Pub Date : 2019-05-14 DOI:10.21608/RPBS.2019.12251.1032

Hala H Zaatout, D. Ghareeb, Alshimaa Abd-Elgwad, A. Ismael

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引用次数: 5

Abstract

Ulva lactuca is widespread green algae. In some regions, it is used in nutrition. Its nutrients include iron, protein, iodine, vitamins (A, B1, and C) and trace elements. Their extracts showed potential antibacterial, hypolipidemic, cardioprotective and chemoprotective activities. The main chemical constituents of Ulva lactuca methanolic crude extract and its fractions were investigated in this study using different phytochemical and chromatographic methods. Biologically guided fractionation of plants or seaweeds extracts is considered the first step in drug discovery. So, the algal crude extract was fractionated then in vitro bioscreened for the determination of diphenylpicrylhydrazyl (DPPH) antioxidant, (Nitric Oxide) NO radical scavenging and anti-inflammatory activities. Results showed that water fraction was the most active fraction. Phenolic content, detected from HPLC, play a role in the antioxidant activity. Finally, it can be concluded that Ulva water fraction is effective candidate to be used in the treatment of oxidative stress and related disorders

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埃及枸杞甲醇提取物的植物化学、抗氧化和抗炎筛选

绿藻是一种分布广泛的绿藻。在一些地区，它被用于营养。它的营养成分包括铁、蛋白质、碘、维生素(A、B1和C)和微量元素。其提取物具有潜在的抗菌、降血脂、心脏保护和化学保护活性。采用不同的植物化学和色谱方法，对芦笋甲醇粗提物及其组分的主要化学成分进行了研究。植物或海藻提取物的生物引导分离被认为是药物发现的第一步。为此，本研究对海藻粗提物进行体外生物筛选，测定其抗氧化二苯基苦酰肼(DPPH)、清除一氧化氮(NO)自由基和抗炎活性。结果表明，水馏分是活性最高的馏分。高效液相色谱法检测酚类物质含量对抗氧化活性有影响。综上所述，Ulva水组分是治疗氧化应激及相关疾病的有效候选物

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Records of Pharmaceutical and Biomedical Sciences

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