Deep brain stimulation removal after successful treatment for heroin addiction

Abstract

Australian & New Zealand Journal of Psychiatry, 54(5) the normal range, and lenograstim increased to 250 μg on 29 June. On 5 July, 11 days after CIA occurrence, the patient’s ANC increased to 9560 cells/ mm3. After that, his ANC returned to a stable range. Examination of HLA alleles revealed the following: HLAA*11:01/24:02, HLA-B*54:01/55:02, HLA-Cw*01:02/03:03, HLA-RB1*04:05/ 08:03, HLA-DQB1*04:01/06:01. Several pharmacogenetic studies found that HLA alleles that differ between ethnics are implicated in the development of CIA (Numata et al., 2018). Because agranulocytosis is a rare adverse drug reaction, only 22 patients with CIA were included for detection of the responsible alleles in a study of Japanese (Saito et al., 2016). We suspected that HLA-DRB1*04:05 is in linkage disequilibrium and HLA-DRB1*04:05 might be an independent risk factor for CIA in Japanese. Further pharmacogenetic studies are needed to clarify the HLA alleles associated with CIA.