Immunomodulation effects of heat-treated Enterococcus faecalis FK-23(FK-23) in mice

Takashi Shimada , Yunqing Cai , Lei Cheng , Chie Motonaga , Kazutake Fukada , Yoshihisa Kitamura , Jieshu Wu
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引用次数: 8

Abstract

Objective

The purpose of this study was to evaluate the effects of Enterococcus faecalis FK-23(FK-23) on the immune function in mice.

Methods

Mice were treated with three doses of the FK-23(0.05, 0.1, 0.2, 0.6 g/kg body weight) for 30 days. Delayed type hypersensitivity (DTH), monocyte phagocytic function, serum hemolysis antibody and natural killer cell activity were studied.

Results

The significant increases in mice treated with 0.6 g/kg bw were found in DTH, phagocytic function of monocyte, serum hemolysis antibody and natural killer cell activity.

Conclusion

The results from the present study suggest that FK-23 could improve both specific and non-specific immune function.

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经热处理的粪肠球菌FK-23(FK-23)对小鼠的免疫调节作用
目的探讨粪肠球菌FK-23(FK-23)对小鼠免疫功能的影响。方法以3种剂量(0.05、0.1、0.2、0.6 g/kg体重)的FK-23治疗smice 30 d。研究延迟型超敏反应(DTH)、单核细胞吞噬功能、血清溶血抗体和自然杀伤细胞活性。结果0.6 g/kg bw组小鼠DTH、单核细胞吞噬功能、血清溶血抗体和自然杀伤细胞活性显著升高。结论FK-23具有改善小鼠特异性和非特异性免疫功能的作用。
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