Investigation of Mechanisms of Regulation of Electromechanical Function of Cardiomyocytes in the Biomechanical Model of Myocardium

V. Sholohov, V. Zverev, A. Kursanov
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Abstract

We developed three-dimensional model of isolated myocardial muscular preparation that takes into account the coupling of excitation with contraction in the myocardium at the cellular and tissue levels. This model describes myocardium sample using approaches and methods developed in continuum mechanics. In the model, electromechanical interactions and mechano-electric feedbacks are realized both at the micro level and at the macro level. We used non-linear partial differential equations describing the deformation of the cardiac tissue, and a detailed "Ekaterinburg-Oxford" (EO) cellular model of the electrical and mechanical activity of cardiomyocytes. Electrical and mechanical interactions between the cells in tissue, as well as intracellular mechano-electric feedback beat-to-beat affect the functional characteristics of coupled cardiomyocytes further, adjusting their electrical and mechanical heterogeneity to the activation timing. Model analysis suggests that cooperative mechanisms of myofilament calcium activation contribute essentially to the generation of cellular functional heterogeneity in contracting cardiac tissue.
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心肌生物力学模型中心肌细胞机电功能调控机制的研究
我们建立了孤立心肌肌肉准备的三维模型,该模型考虑了细胞和组织水平上心肌兴奋与收缩的耦合。该模型使用连续介质力学的方法来描述心肌样本。该模型在微观层面和宏观层面都实现了机电相互作用和机电反馈。我们使用非线性偏微分方程来描述心脏组织的变形,并使用详细的“叶卡捷琳堡-牛津”(EO)细胞模型来描述心肌细胞的电和机械活动。组织中细胞之间的电和机械相互作用以及细胞内的机电反馈搏动进一步影响耦合心肌细胞的功能特征,调整其电和机械异质性以适应激活时间。模型分析表明,肌丝钙活化的协同机制在收缩心脏组织中产生了细胞功能异质性。
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