Comparison of Rates of Nephrotoxicity Associated with Vancomycin in Combination with Piperacillin‐Tazobactam Administered as an Extended versus Standard Infusion

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Pub Date : 2017-03-01 DOI:10.1002/phar.1901
Mariam Mousavi, Tanya Zapolskaya, Marco R Scipione, E. Louie, J. Papadopoulos, Yanina Dubrovskaya
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引用次数: 13

Abstract

Despite recent reports of relatively high rates (16–37%) of acute kidney injury (AKI) in patients receiving the combination of intravenous piperacillin‐tazobactam (PTZ) and vancomycin, data are limited evaluating the impact of PTZ infusion strategy on the occurrence of nephrotoxicity. The objective of this study was to compare the rates of nephrotoxicity in patients receiving vancomycin in combination with PTZ administered as an extended infusion (EI) versus a standard infusion (SI).
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万古霉素联合哌拉西林-他唑巴坦长期输注与标准输注肾毒性的比较
尽管最近有报道称，在接受静脉注射哌拉西林-他唑巴坦(PTZ)和万古霉素联合治疗的患者中，急性肾损伤(AKI)发生率相对较高(16-37%)，但评估PTZ输注策略对肾毒性发生的影响的数据有限。本研究的目的是比较接受万古霉素联合PTZ作为延长输注(EI)与标准输注(SI)的患者肾毒性发生率。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
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