Integrating Particle Microstructure, Surface and Mechanical Characterization with Bulk Powder Processing

IF 2.6 4区 材料科学 Q3 ENGINEERING, CHEMICAL KONA Powder and Particle Journal Pub Date : 2020-01-10 DOI:10.14356/kona.2020008
R. Pinal, M. Carvajal
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引用次数: 1

Abstract

Multiple industrial applications, including pharmaceuticals, rely on the processing of powders. The current powder characterization framework is fragmented into two general areas. One deals with understanding powders from the standpoint of its constituting agents—particles. The other deals with understanding based on the bulk— the collective behavior of particles. While complementary, the two aspects provide distinct pieces of information. Whenever possible, experimental techniques should be used to predict powder behavior. However, it is equally important to recognize that because of the natural complexity of powders, existing predictive approaches will continue to be of limited success for predicting the collective behavior of particles. This article discusses the understanding of powder properties from two perspectives. One is the effect of surface energy at the bulk level (large collections of particles), which controls interactions between powders. This aspect is most useful if studied at the bulk-powder level, not at the single-particle level. Another perspective deals with the physico-mechanical properties of individual particles, responsible for the observed behavior of powders when subjected to mechanical stress from unit operations such as milling. This aspect, which controls the failure mechanism of powders subjected to milling, is most useful if assessed at the single-particle, not at the bulk level. Therefore, in order to fully understand, and eventually predict, or at least effectively model powder behavior, a good-judgement-based combination of microscopic and bulk-level analytical methods is necessary.
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将颗粒微观结构、表面和力学特性与散装粉末加工相结合
包括制药在内的多种工业应用都依赖于粉末的加工。目前的粉末表征框架分为两个主要领域。一种是从粉末的构成物——粒子的角度来理解粉末。另一种是基于体积的理解——粒子的集体行为。虽然互补,但这两个方面提供了不同的信息。只要有可能,实验技术应用于预测粉末的行为。然而,同样重要的是要认识到,由于粉末的天然复杂性,现有的预测方法对于预测粒子的集体行为将继续是有限的成功。本文从两个方面讨论了对粉末性能的认识。一个是表面能在体积水平(大颗粒集合)的影响,它控制粉末之间的相互作用。这方面是最有用的,如果研究在散装粉水平,而不是在单颗粒水平。另一种观点处理单个颗粒的物理机械特性,负责观察粉末在受到机械应力时的行为,如铣削。这方面,它控制的破坏机制的粉末经受碾磨,是最有用的,如果评估在单颗粒,而不是在散装水平。因此,为了充分理解,并最终预测,或至少有效地模拟粉末的行为,一个良好的判断为基础的结合微观和体积级分析方法是必要的。
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来源期刊
KONA Powder and Particle Journal
KONA Powder and Particle Journal 工程技术-材料科学:综合
CiteScore
8.40
自引率
4.90%
发文量
35
审稿时长
>12 weeks
期刊介绍: KONA publishes papers in the broad field of powder science and technology, ranging from fundamental principles to practical applications. Papers describing technological experience and critical reviews of existing knowledge in special areas are also welcome.
期刊最新文献
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