Synthesis and bio-activity of complex azo compounds: A review on formazans and its complexes

IF 1.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Main Group Chemistry Pub Date : 2023-04-20 DOI:10.3233/mgc-230014
Neetu Singh, H. S. Sohal, M. Verma, R. Sharma, Manvinder Kaur
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Abstract

Formazans are well-known complexing agents and form highly stable complexes with verity of metals that are useful for number of pharmaceutical applications. The activity profile of formazans and their complexes are huge that include antibacterial, antifungal, antioxidant, anti-fertility, anti-tubercular, antiviral, anti-inflammatory, anticancer, anti-HIV, and anti-proliferative are among the biological activities covered by the formazans. The structures, synthesis, reactions, and spectral properties of formazans have been studied to highlight their potential applications in a variety of bioactive phenomena and analytical applications. The biological potential of the compounds will be greatly enhanced when substitution is carried out at R and R2. We observed that electron withdrawing groups at para position (if R, R1 & R2 = phenyl ring) are the best substitutions to achieve potent pharmacological activities.
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偶氮络合物的合成及其生物活性:甲酸甲酯及其络合物的研究进展
Formazans是一种著名的络合剂,与多种金属形成高度稳定的配合物,在许多药物应用中都很有用。formazans及其复合物具有广泛的生物活性,包括抗菌、抗真菌、抗氧化、抗生育、抗结核、抗病毒、抗炎、抗癌、抗艾滋病毒和抗增殖等。本文对甲酸甲酯的结构、合成、反应和光谱性质进行了研究,以突出其在各种生物活性现象和分析应用中的潜在应用。当在R和R2处进行取代时,化合物的生物潜力将大大增强。我们观察到对位上的吸电子基团(如果R, R1和R2 =苯环)是获得有效药理活性的最佳取代。
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来源期刊
Main Group Chemistry
Main Group Chemistry 化学-化学综合
CiteScore
2.00
自引率
26.70%
发文量
65
审稿时长
>12 weeks
期刊介绍: Main Group Chemistry is intended to be a primary resource for all chemistry, engineering, biological, and materials researchers in both academia and in industry with an interest in the elements from the groups 1, 2, 12–18, lanthanides and actinides. The journal is committed to maintaining a high standard for its publications. This will be ensured by a rigorous peer-review process with most articles being reviewed by at least one editorial board member. Additionally, all manuscripts will be proofread and corrected by a dedicated copy editor located at the University of Kentucky.
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