물봉선 메탄올추출물의 항 주름 효과

Abstract

We evaluated the anti-wrinkle effects of Impatiens textori methanol extract (ITME). ITME treatment at 10 mg/mL decreased collagenase and elastase activity by 50.4% and 54.9%, respectively. In tests of human dermal fibroblast cytotoxicity, the maximum permissible level of ITME treatment was greater than 200 μg/mL. When compared to a control: i) treatment with 200 μg/mL of ITME significantly increased type I procollagen synthesis by 36.7% (p<0.05), and ii) treatment with 100 μg/mL ITME significantly decreased MMP-1 mRNA and protein expression by 23.1% and 35.3%, respectively (p< 0.01). Treatment with ITME resulted in a promotion of collagen synthesis and inhibition of collagen degradation in human dermal fibroblasts. Collectively, these results suggest that ITME could be used as functional cosmetic material to prevent or alleviate skin wrinkles induced by ultraviolet rays.