Syntheses and aggregation properties of new squalene receptors bearing open chain ligands

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Supramolecular Chemistry Pub Date : 2021-05-04 DOI:10.1080/10610278.2021.1970161

Tran Ngoc Linh, T. Arimura, Kenichi Tominaga, H. Kigoshi, H. Isoda

引用次数: 1

Abstract

ABSTRACT New squalene receptors bearing open-chain polyether ligands (SQ-diEG, SQ-triEG, SQ-tetraEG) were synthesised. The stoichiometries and association constants ( K a) for the interactions between these squalene receptors and representative alkaline earth metal ions (Mg2+, Ca2+, and Ba2+) were determined in solution. Fluorescence spectral studies revealed that the squalene receptors self-associate with critical vesicle concentrations at 25 °C of 2.2 × 10−5 M for SQ-diEG, 2.3 × 10−5 M for SQ-triEG, and 2.5 × 10−5 M for SQ-tetraEG. The self-assembly behaviour was probed using laser diffraction particle size-based analyses and scanning electron microscopy. A decrease in the SQ-tetraEG vesicle size was readily induced by the addition of alkaline earth metal ions, confirmed by cryogenic transmission electron microscopy. Graphical abstract

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新型开链配体角鲨烯受体的合成及聚集性质

摘要合成了新型开链聚醚配体角鲨烯受体(SQ-diEG、SQ-triEG、SQ-tetraEG)。测定了这些角鲨烯受体与代表性碱土金属离子(Mg2+、Ca2+和Ba2+)相互作用的化学计量学和缔合常数(K a)。荧光光谱研究表明，角鲨烯受体与25°C时的临界囊泡浓度(SQ-diEG为2.2 × 10−5 M, SQ-triEG为2.3 × 10−5 M, SQ-tetraEG为2.5 × 10−5 M)自相关。利用激光衍射粒度分析和扫描电镜对其自组装行为进行了研究。低温透射电镜证实，加入碱土金属离子后，SQ-tetraEG囊泡大小明显减小。图形抽象

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来源期刊

Supramolecular Chemistry 化学-化学综合

CiteScore

3.60

自引率

3.00%

发文量

审稿时长

2.7 months

期刊介绍： Supramolecular Chemistry welcomes manuscripts from the fields and sub-disciplines related to supramolecular chemistry and non-covalent interactions. From host-guest chemistry, self-assembly and systems chemistry, through materials chemistry and biochemical systems, we interpret supramolecular chemistry in the broadest possible sense. Interdisciplinary manuscripts are particularly encouraged. Manuscript types include: high priority communications; full papers; reviews, and; Methods papers, techniques tutorials highlighting procedures and technologies that are important to the field. We aim to publish papers in a timely fashion and as soon as a paper has been accepted and typeset it will be published in electronic form on the Latest articles section of the website. The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field. Under normal circumstances, Supramolecular Chemistry does not consider manuscripts that would be more suitable in a highly specialized journal. This includes, but is not limited to, those based mostly or exclusively on topics such as solid state/X-ray structures, computational chemistry, or electrochemistry. . The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field.