Morphological and histological changes induced by arsenic trioxide in mice offspring

Abstract

Introduction: is a standout amongst the most lethal metals derived from the natural environment. The major reason for human arsenic toxicity is tainting of drinking water. Arsenic trioxide is inorganic arsenic that is classified by the US Environmental Protection Agency as a known human carcinogen. Aim: Illustration of morphological and histological effects of arsenic trioxide on mice offspring. Methods: Adult female albino mice were divided into five groups: Control, negative control treated with Hcl (arsenic trioxide solvent), and three groups daily treated orally with different doses of arsenic trioxide (0.3, 0.7 and 1 mg/kg). Offspring of 21 day old mice were morphologically examined, weighed and morphometric measurements were carried out. Liver and kidney were histopathologically examined. Results: Data showed a significant decrease in body weight and crown rump length in the arsenic high dose treated group and a significant