P. Sanders, G. Moulin, C. Gaudiche, B. Delepine, D. Mourot
{"title":"Comparison of automated liquid chromatographic and bioassay methods for determining spiramycin concentration in bovine plasma.","authors":"P. Sanders, G. Moulin, C. Gaudiche, B. Delepine, D. Mourot","doi":"10.1093/JAOAC/74.6.912","DOIUrl":null,"url":null,"abstract":"The performance of a liquid chromatographic (LC) method for spiramycin measurement in bovine plasma has been compared with that of a microbiological method. Plasma samples were obtained from cattle administered spiramycin intravenously. Comparison tests used were intraclass correlation (r1), correlation (r), and Student's paired t-test. For concentrations lower than 2.5 IU/mL, microbiological values were higher than LC values. This difference in results modified pharmacokinetic interpretation and might be explained by the presence of microbiologically active metabolites.","PeriodicalId":14752,"journal":{"name":"Journal - Association of Official Analytical Chemists","volume":"5 1","pages":"912-7"},"PeriodicalIF":0.0000,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal - Association of Official Analytical Chemists","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/JAOAC/74.6.912","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
The performance of a liquid chromatographic (LC) method for spiramycin measurement in bovine plasma has been compared with that of a microbiological method. Plasma samples were obtained from cattle administered spiramycin intravenously. Comparison tests used were intraclass correlation (r1), correlation (r), and Student's paired t-test. For concentrations lower than 2.5 IU/mL, microbiological values were higher than LC values. This difference in results modified pharmacokinetic interpretation and might be explained by the presence of microbiologically active metabolites.
IF 0 CureusPub Date : 2021-08-31DOI: 10.7759/cureus.17605
Emily Hotez, Candace M Gragnani, Priyanka Fernandes, Kashia A Rosenau, Apsara Chopra, Ada Chung, Julie Grassian, Sydney Huynh, Tayloneei Jackson, Kevin Jimenez, Eric Jue, Nancy Le, Jennifer Lenghong, Alejandrina Lopez, Lizzet Lopez, Pearl Omo-Sowho, Kennedy Pennington, Richard Tirado, Alice Kuo
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