Levomilnacipran (Fetzima™) for the treatment of major depressive disorder

C. Ross
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Abstract

Levomilnacipran (Fetzima™) was approved by the United States Food and Drug Administration (FDA) in July 2013 for the treatment of Major Depressive Disorder (MDD) in adults. Levomilnacipran is the (1S,2R) enantiomer of racemic milnacipran and represents one of the newest medications designed and marketed as an enantiomer of an already approved medication with hopes of improving efficacy and limiting side effects. This article reviews the evidence supporting the use of milnacipran for MDD, examines the clinical studies behind levomilnacipran's approval, and discusses practical considerations regarding the use of this new antidepressant medication.
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左旋美那西普兰(Fetzima™)用于治疗重度抑郁症
左旋蜜那西普兰(Fetzima™)于2013年7月被美国食品和药物管理局(FDA)批准用于治疗成人重度抑郁症(MDD)。左旋密那西普兰是外消旋密那西普兰的(1S,2R)对映体,代表了一种最新的药物设计和销售,作为已经批准的药物的对映体,希望能提高疗效和限制副作用。本文回顾了支持使用milnacpran治疗重度抑郁症的证据,检查了左旋milnacpran批准的临床研究,并讨论了使用这种新型抗抑郁药物的实际考虑。
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