Ectopic Expression of DSCR1 in Conjunction with NDV Infection Reduces VEGF and Induces Apoptosis in Lung Cancer A549 Cell Line

Abstract

Lung cancer is the second newly diagnosed cancer that accounts for the most related cancer-deaths in both genders in the world [3,4]. The primary lung cancer can grow locally or cause metastasis in other tissues [4]. The most frequent lung cancers is Non-Small Cell Lung Cancer (NSCLC) that consist of 80% of all kinds of lung cancer [5-7]. Despite of conventional therapies and novel progressed techniques in diagnosis and therapy, breast cancer still a devastating disease worldwide, therefore it has provided an incentive for searching of new more effective and with less side effect therapeutics. The purpose of cancer therapy is to destroy malignant cells without causing destruction of normal cells. One of the novel therapeutic that gives much hopes is using of oncolytic viruses that can selectively replicate in cancer cells [8].