{"title":"Stereoselective Aminomethylation of m-Cresol with Chiral Amine Mediated by 4 A0 Molecular Sieves Under Neat Conditions","authors":"M. Gholizadeh","doi":"10.2174/1876214X00902010054","DOIUrl":null,"url":null,"abstract":"A minomethylation at ortho position with respect to hydroxyl group of mcresol in presence carefully dried 4A molecular sieves under neat conditions. One pot, two component,Mannich reaction of m-cresol with imine at 600C temperature under solvent free conditions affords the corresponding aminomethylated products in good yields, with moderate stereoselectivity.","PeriodicalId":22755,"journal":{"name":"The Open Catalysis Journal","volume":"23 1","pages":"54-60"},"PeriodicalIF":0.0000,"publicationDate":"2009-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Catalysis Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1876214X00902010054","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A minomethylation at ortho position with respect to hydroxyl group of mcresol in presence carefully dried 4A molecular sieves under neat conditions. One pot, two component,Mannich reaction of m-cresol with imine at 600C temperature under solvent free conditions affords the corresponding aminomethylated products in good yields, with moderate stereoselectivity.
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