Reasoning and discovering novel treatments in linked social health records

P. Cappellari, Soon Ae Chun, Dennis Shpitz
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Abstract

Discovering novel, alternative treatment options that may have the same efficacy and patient safety as existing drugs is a challenging task for clinicians. Through research and observations, clinicians can form a hypothesis about a possible compatible option, but it is difficult to support or refute it. In this study, we present an approach that utilizes the Semantically Linked Data of different Social Health Records (SHR), which contain patient-generated, health-related contents. The SHRs can provide information about the crowd of online patients' health practices that is lacking within specific Electronic Health Records (EHR) systems. We present the Linked Data framework for building an SHR knowledge base, and describe methods for reasoning and discovering potential novel alternative treatment options, as well as an approach for gathering support that an alternative treatment can indeed be substituted for standard treatment options.
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在相关的社会健康记录中推理和发现新的治疗方法
对于临床医生来说,发现可能与现有药物具有相同疗效和患者安全性的新颖替代治疗方案是一项具有挑战性的任务。通过研究和观察,临床医生可以对可能的兼容选择形成假设,但很难支持或反驳它。在本研究中,我们提出了一种利用不同社会健康记录(SHR)的语义关联数据的方法,其中包含患者生成的与健康相关的内容。SHRs可以提供特定电子健康记录(EHR)系统所缺乏的关于大量在线患者健康实践的信息。我们提出了用于构建SHR知识库的关联数据框架,并描述了推理和发现潜在的新颖替代治疗方案的方法,以及收集支持替代治疗方案确实可以替代标准治疗方案的方法。
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