Study of the relation between Plasma Transfusion and Clinical Outcome in Critically Ill Children at Pediatric Intensive Care Unit

Abstract

Background: Plasma transfusions are commonly used in adult and paediatric intensive care units. Latest data showed a correlation in adult trauma patients between plasma transfusions and worse clinical results. Plasma transfusions are frequently prescribed worldwide; the indications for their use remain unclear. Objective: To identify signs of plasma transfusions and evaluation of the impact of plasma transfusions on coagulation studies. Patients and Methods: This prospective cohort study was conducted at the Pediatric Intensive Care unit, Zagazig University Hospital between July 2019 and January 2020. Participants in the study had a full background of socio-demographic characteristics. Total clinical examination and the seriousness of the disease was measured at admission using the Sequential Organ Failure Assessment (SOFA) score as per Ferreira 2001. Patients have been checked for critical parameters. Results: Our analysis found that 50 percent of plasma transfusions were attributed to bleeding, 40.7 percent to hypoalbuminemia, and 9.3 percent of plasma transfusions were due to surgical conceptions. The mortality rate in our study was 25.9 percent. Conclusion: Plasma transfusion does not have a statistical effect on mortality, but there has been little improvement in mortality over predictive SOFA mortality. Approximately ten times, no bleeding or proposed bleeding-risk operations earned plasma, based on the physician's views and conceptions. Plasma transfusion was insufficient to correct minor coagulation irregularities. Major research evaluating effective plasma transfusion techniques are desperately needed.