Synthesis and Antifungal Evaluation of Quaternary Ammonium Salts Derivatives of Dialkylaminoethyl Methacrylate Bearing 1,3,4-Oxadiazoles Moieties

Zahra Ould Kada, T. Benaissa, N. Hamini-Kadar, S. Daoudi
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Abstract

Starting from lauric acid two novel quaternary ammonium salts containing 1,3,4-Oxadiazoles nucleus derivative from N,N-Diethylaminoethyl Methacrylate (DEAEMA) and N,N-Dimethylaminoethyl Methacrylate (DMAEMA) was successfully synthesized and characterized by IR, 1H and 13C NMR, All the synthesized compounds were evaluated for their preliminary in vitro antifungal activity against three fungal strains such as Fusarium oxysporum, Fusarium commune and Fusarium rodelens. The synthesized compounds showed promising antifungal potential against the phytopathogenic test fungi.
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含1,3,4-恶二唑基甲基丙烯酸二胺乙酯季铵盐衍生物的合成及抑菌性评价
以月桂酸为原料,成功合成了N,N-二乙基氨基乙基甲基丙烯酸酯(DEAEMA)和N,N-二甲基氨基乙基甲基丙烯酸酯(DMAEMA)两种新型含1,3,4-恶二唑的季铵盐,并通过IR、1H和13C NMR对其进行了初步的体外抑菌活性评价,对3种真菌菌株镰刀菌(Fusarium oxysporum, Fusarium commune, Fusarium rodelens)进行了初步的体外抑菌活性评价。合成的化合物对植物致病试验真菌具有良好的抗真菌活性。
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