Acute Anterior Uveitis in patients with ankylosing spondylitis in northeast of Iran

M. Jokar, Mina Jokar
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引用次数: 2

Abstract

Personal non-commercial use only.Rheumatology Research Journal. Copyright © 2019. All rights reserved *Corresponding Author: Mohammadhassan Jokar, MD; Department of Internal Medicine, Imam Reza Hospital, Mashhad, Iran, Tel/Fax: (+98) 511-8598818 Received: 01 September 2018 ; Accepted: 05 January 2019 Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disorder with variable clinical manifestations. Acute anterior uveitis is the most common extra-articular manifestation of ankylosing spondylitis. This study assessed the prevalence of uveitis in patients with ankylosing spondylitis in Mashhad, Iran. In this retrospective study, the medical records of patients diagnosed with AS between January 1st, 2007 and December 31st, 2017 in a rheumatology clinic in Mashhad, Iran were reviewed. Diagnoses of ankylosing spondylitis were made based on the modified New York criteria. The records of 317 patients were reviewed (81.4% male, 18.6% female, with a male to female ratio of 4.3:1). The mean age at onset of AS was 27.01±8.63 years (minimum 12 years, maximum 55 years). The mean age at diagnosis of AS was 30.72±9.44 years. The mean age at diagnosis of uveitis was 32.40±10.49 years. The mean follow-up period of patients was 6.19±5.51 years. HLA-B27 was positive in 77% of patients. About 14% of patients had uveitis in the mean follow-up period of 6.19±5.51 years. The frequency of uveitis in patients with AS is lower in the study region than in most other regions. Future studies with a prospetive design, randomized patient selection, and lifelong follow up can provide a more accurate description of acute anterior uveitis in patients with AS.
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伊朗东北部强直性脊柱炎患者的急性前葡萄膜炎
仅供个人非商业用途。风湿病研究杂志。版权所有©2019。*通讯作者:Mohammadhassan Jokar, MD;伊朗马什哈德伊玛目礼萨医院内科,电话/传真:(+98)511-8598818收件日期:2018年9月1日;强直性脊柱炎(AS)是一种具有多种临床表现的慢性炎症性风湿病。急性前葡萄膜炎是强直性脊柱炎最常见的关节外表现。本研究评估了伊朗马什哈德强直性脊柱炎患者葡萄膜炎的患病率。在这项回顾性研究中,回顾了2007年1月1日至2017年12月31日在伊朗马什哈德一家风湿病诊所诊断为AS的患者的医疗记录。强直性脊柱炎的诊断是基于修改后的纽约标准。其中男性81.4%,女性18.6%,男女比例为4.3:1。平均发病年龄27.01±8.63岁(最小12岁,最大55岁)。AS的平均诊断年龄为30.72±9.44岁。葡萄膜炎的平均诊断年龄为32.40±10.49岁。患者平均随访时间为6.19±5.51年。77%的患者HLA-B27呈阳性。平均随访6.19±5.51年,约14%的患者出现葡萄膜炎。AS患者发生葡萄膜炎的频率在该研究地区低于大多数其他地区。未来的研究采用前瞻性设计、随机患者选择和终身随访,可以更准确地描述AS患者的急性前葡萄膜炎。
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