T. Fujii, Y. Arai, A. Kubota, K. Togawa, N. Mizushima, I. Mikuni
{"title":"Quality Test of Ketotifen Eye Drops Prepared in Hospital : (2) The Irritability Test","authors":"T. Fujii, Y. Arai, A. Kubota, K. Togawa, N. Mizushima, I. Mikuni","doi":"10.5649/JJPHCS1975.10.171","DOIUrl":null,"url":null,"abstract":"Stability on preservation of Ketotifen Eye Drops prepared in our hospital for treatment of conjunctivitis due to Japanese cedar pollinosis was examined. The suitability of its heat sterilization was also studied. After storing for 3 months at room temperature or 6 months in a cold place, no changes were observed in appearance and physical properties of the solution. The rate of residual Ketotifen was more than 90%. After sterilization at 105°C for 15 minutes, coloration, .decrease in content, decomposed products were observed, and sterilization by heating seemed impossible. However, it is considered that Ketotifen Eye Drops be useful if it is prepared in the germ-free conditions and preserved in a cold place.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"109 1","pages":"177-181"},"PeriodicalIF":0.0000,"publicationDate":"1984-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Nippon Hospital Pharmacists Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5649/JJPHCS1975.10.171","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Stability on preservation of Ketotifen Eye Drops prepared in our hospital for treatment of conjunctivitis due to Japanese cedar pollinosis was examined. The suitability of its heat sterilization was also studied. After storing for 3 months at room temperature or 6 months in a cold place, no changes were observed in appearance and physical properties of the solution. The rate of residual Ketotifen was more than 90%. After sterilization at 105°C for 15 minutes, coloration, .decrease in content, decomposed products were observed, and sterilization by heating seemed impossible. However, it is considered that Ketotifen Eye Drops be useful if it is prepared in the germ-free conditions and preserved in a cold place.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
