Optimization and Evaluation of Oleic Acid Based Unsaturated Fatty AcidLiposomes Gel

Abstract

Oxiconazole loaded Unsaturated Fatty Acid Liposomes (UFL) was used as a transdermal formulation in treatment of chronic fungal infections. Oxiconazole has low oral bioavailability of drug and short half-life that’s why preferring this transdermal route for proper treatment against fungal infections. UFL was made by using oleic acid and tween 80 in different proportion, batches were developed by using a central composite design. The optimal UFL-6 formulation has shown maximum entrapment efficiency (61.05%) and good vesicle size (215 nm). The oxiconazole release from UFLG-6 gels, follow Higuchi model and drug permeation via a cellophane membrane was maximum in comparison to other gel formulations. The UFLG-6 formulation also shows maximum antifungal activity against Candida albicans fungus.