Probing Brain Oxygenation Wave-forms with Near Infrared Spectroscopy (NIRS)

A. Gersten, Jacqueline Perle, D. Heimer, A. Raz, R. Fried
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引用次数: 5

Abstract

The technique of near infrared spectroscopy (NIRS) allows to measure the oxygenation of the brain tissue. The particular problems involved in detecting regional brain oxygenation (rSO2) are discussed. The dominant chromophore (light absorber) in tissue is water. Only in the NIR light region of 650-1000 nm, the overall absorption is sufficiently low, and the NIR light can be detected across a thick layer of tissues, among them the skin, the scull and the brain. In this region, there are many absorbing light chromophores, but only three are important as far as the oxygenation is concerned. They are the hemoglobin (HbO2), the deoxy-hemoglobin (Hb) and cytochrome oxidase (CtOx). The devices that were used in our experiments were : Somanetics INVOS Brain Oximeter (IBO) and Toomim's HEG spectrophotometer. The performances of both devices were compared including their merits and drawbacks. The IBO use for research has two drawbacks: the sampling rate is too small and the readings are limited to only two significant digits. The HEG device does not have these drawbacks, but is not developed sufficiently at this time to measure rSO2. We have measured the HEG readings and compared them with the rSO2 readings of the IBO. Results of an experiment are presented whose aim is to explore the relationship between respiration and cerebral oxygenation. Measurements of end tidal CO2 (EtCO2) were taken simultaneously with cerebral oxygen saturation (rSO2) using the INVOS Cerebral Oximeter of Somanetics. Due to the device limitations we could explore only subjects who could perform with a breathing rate of around 2/min or less. The results of all subjects clearly show a periodic change of cerebral oxygenation with the same period as the breathing exercises.
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近红外光谱探测脑氧合波形
近红外光谱(NIRS)技术可以测量脑组织的氧合。讨论了检测区域脑氧合(rSO2)所涉及的特殊问题。组织中主要的发色团(光吸收体)是水。只有在650- 1000nm的近红外光区域,整体吸收率才足够低,近红外光可以穿透一层厚厚的组织,其中包括皮肤、头骨和大脑。在这个区域,有许多吸收光的发色团,但就氧合作用而言,只有三个是重要的。它们是血红蛋白(HbO2)、脱氧血红蛋白(Hb)和细胞色素氧化酶(CtOx)。实验中使用的仪器有:Somanetics INVOS脑血氧仪(IBO)和Toomim HEG分光光度计。比较了两种器件的性能,包括它们的优缺点。IBO用于研究有两个缺点:采样率太小,读数仅限于两位有效数字。HEG设备没有这些缺点,但目前还没有足够的发展来测量rSO2。我们测量了HEG读数,并将其与IBO的rSO2读数进行了比较。本文介绍了一项旨在探讨呼吸与脑氧合关系的实验结果。采用INVOS脑血氧仪同时测定末潮CO2 (EtCO2)和脑氧饱和度(rSO2)。由于设备的限制,我们只能探索那些呼吸频率约为2/min或更低的受试者。所有受试者的结果都清楚地表明,随着呼吸练习的进行,大脑氧合的周期性变化。
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IF 0 arXiv: Biological PhysicsPub Date : 2009-03-02 DOI: 10.14704/NQ.2009.7.2.229
A. Gersten, Jacqueline Perle, A. Raz, R. Fried
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