{"title":"Analyzing dispersion effects from replicated order-of-addition experiments","authors":"Shin-Fu Tsai","doi":"10.1080/00224065.2022.2110024","DOIUrl":null,"url":null,"abstract":"Abstract Dispersion effects may play a vital role, in addition to location effects, in exploring optimal addition orders of several materials in some chemical, industrial and pharmaceutical studies. Two replication-based statistical methods developed using frequentist and fiducial probability arguments are introduced in this paper to identify active dispersion effects from replicated order-of-addition experiments. Simulation results show that both approaches can maintain empirical sizes sufficiently close to the nominal level while their finite-sample performances are very similar. From a statistical perspective, the fiducial method can provide a unified probability framework to analyze dispersion effects as well as location effects. However, it is computationally more expensive than the frequentist method. Consequently, the frequentist method is recommended for real-world applications due to its low computational cost. A drug combination study is used to illustrate these two approaches. In addition, some eligible order-of-addition designs are collected in a catalogue for future work.","PeriodicalId":54769,"journal":{"name":"Journal of Quality Technology","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Quality Technology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/00224065.2022.2110024","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, INDUSTRIAL","Score":null,"Total":0}
引用次数: 2
Abstract
Abstract Dispersion effects may play a vital role, in addition to location effects, in exploring optimal addition orders of several materials in some chemical, industrial and pharmaceutical studies. Two replication-based statistical methods developed using frequentist and fiducial probability arguments are introduced in this paper to identify active dispersion effects from replicated order-of-addition experiments. Simulation results show that both approaches can maintain empirical sizes sufficiently close to the nominal level while their finite-sample performances are very similar. From a statistical perspective, the fiducial method can provide a unified probability framework to analyze dispersion effects as well as location effects. However, it is computationally more expensive than the frequentist method. Consequently, the frequentist method is recommended for real-world applications due to its low computational cost. A drug combination study is used to illustrate these two approaches. In addition, some eligible order-of-addition designs are collected in a catalogue for future work.
期刊介绍:
The objective of Journal of Quality Technology is to contribute to the technical advancement of the field of quality technology by publishing papers that emphasize the practical applicability of new techniques, instructive examples of the operation of existing techniques and results of historical researches. Expository, review, and tutorial papers are also acceptable if they are written in a style suitable for practicing engineers.
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