{"title":"A new neutral-lipophilic 99mTc complex with a bis-hydrazide-phosphine (BHP) ligand","authors":"K.V. Katti , P.R. Singh , W.A. Volkert , A.R. Ketring , K.K. Katti","doi":"10.1016/0883-2889(92)90059-N","DOIUrl":null,"url":null,"abstract":"<div><p>A new bis-hydrazide-phosphine (BHP) ligand was synthesized, characterized and complexed with <sup>99m</sup>Tc. <sup>99m</sup>Tc phenyl-BHP (PBHP) was shown to form a neutral-lipophilic chelate with <sup>99m</sup>Tc, in high yields, that is stable over a wide pH range. Results with <sup>99m</sup>Tc-PBHP indicate that the BHP chelating moiety is attractive for use in designing new <sup>99m</sup>Tc-imaging agents.</p></div>","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1992-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90059-N","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/088328899290059N","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
A new bis-hydrazide-phosphine (BHP) ligand was synthesized, characterized and complexed with 99mTc. 99mTc phenyl-BHP (PBHP) was shown to form a neutral-lipophilic chelate with 99mTc, in high yields, that is stable over a wide pH range. Results with 99mTc-PBHP indicate that the BHP chelating moiety is attractive for use in designing new 99mTc-imaging agents.
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