Patterns of ADRs and Risk Factors Involved: Study In Cardiology Unit Of An Indian Tertiary Care Center

Abstract

Objective: There is paucity of data regarding adverse drug reaction (ADR) monitoring in India as whole; particularly so in cardiology department. Most of the patients in cardiology department have co-morbidity and are on polypharmacy. So ADRs are very common. Present study was commenced to monitor the pattern of ADRs and the risk factors involved in cardiac patients.Materials and Methods: A prospective, observational study was conducted over one year. ADR profile was noted by spontaneous reporting and intensive monitoring.Results: A total of 208 ADRs were reported from 188 patients (19.5%). Overall ADRs were more common in females than in males (27.9% vs 15.8%). Incidence also increases with age. Nitrates were the most common offender drug group (17.8%).Conclusion: Development of ADR in one out of every five cardiac patients points toward the gravity of the situation. Female gender and age above 65 years are independent risk factors for development of ADRs.