The role of interactions of nucleic acids with lipids in nuclear pore assembly, genome expression and carcinogenesis

Abstract

In our days when the methods of molecular genetics are dominant in biology, traditional biochemistry and biophysics rank low and serve as Cinderella in molecular biology. Unfortunately, biochemists and biophysicist do not have enough time to estimate new methods (protocols) that emerged in molecular biology and genetics. The demerits of the methods are multiplied giving birth to other errors. The example of it is an approximately thirty‒year investigation of nuclear matrix, which according to recent data does not exist in the structure of nucleus! Furthermore, a lot of valuable ideas which were rejected because of the absence of appropriate biochemical methods in the past have not been recovered and don’t got a development after the appearance of the techniques which could be used to explain their correctness. One of the undeservingly forgotten ideas, which was exploited during investigation within 70s‒80s in the past century, was the conception of DNA‒membrane complexes,1 and as a particular case, DNA‒lipid interactions.