{"title":"Preparation of poly(acrylamide-co-Acrylonitrile) thermosensitivity microgel and control release of aspirin","authors":"S. Cai, X. Li, Shijie Pu, Xinyu Ma, Xianru He","doi":"10.1080/00914037.2022.2090355","DOIUrl":null,"url":null,"abstract":"Abstract To extend the release time of drug carriers with the thermoresponsive behavior of upper critical solution temperature (UCST), P(AAm-co-AN) microgels are prepared by precipitation polymerization. It is found that the microgels exhibit the UCST-type response and the microgel shows swelling and disperses well when the temperature is higher than the critical temperature. Because the microgel can swell and shrink reversibly with the change in solution temperature, it can be used as a drug carrier. Compared with the micellar carrier, the microgel carrier’s structure is more stable and has a better sustained-release effect. Graphical Abstract","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":"27 1","pages":"1142 - 1150"},"PeriodicalIF":2.5000,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Polymeric Materials and Polymeric Biomaterials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/00914037.2022.2090355","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 1
Abstract
Abstract To extend the release time of drug carriers with the thermoresponsive behavior of upper critical solution temperature (UCST), P(AAm-co-AN) microgels are prepared by precipitation polymerization. It is found that the microgels exhibit the UCST-type response and the microgel shows swelling and disperses well when the temperature is higher than the critical temperature. Because the microgel can swell and shrink reversibly with the change in solution temperature, it can be used as a drug carrier. Compared with the micellar carrier, the microgel carrier’s structure is more stable and has a better sustained-release effect. Graphical Abstract
期刊介绍：
International Journal of Polymeric Materials and Polymeric Biomaterials is the official publication of the International Society for Biomedical Polymers and Polymeric Biomaterials (ISBPPB). This journal provides a forum for the publication of peer-reviewed, English language articles and select reviews on all aspects of polymeric materials and biomedical polymers. Being interdisciplinary in nature, this journal publishes extensive contributions in the areas of encapsulation and controlled release technologies to address innovation needs as well.
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