IMMUNOHISTOCHEMICAL CHARACTERISTICS OF ENDOMETRIAL TISSUES IN HYPERPLASTIC PROCESSES

Abstract

To determine the degree of dependence between the histological variants of HPE (non-atypical EH (NAEH), Hyperplastic processes of the endometrium (HPE) are a common pathology of the female reproductive system. Excess estrogenic stimulation is a significant role in their development in the case of insufficient progesterone influ - ence. Estrogen receptors (ER) alpha are the main isoforms that mediate endometrial proliferation in hyperplastic processes. Our study aimed to determine the degree of ER expression in different types of HPE and to study the dependence of their expression on the histological variant and anthropometric indicators. Tissue samples were divided into groups depending on the obtained result of histological examination, namely, atypical endometrial hyperplasia, endometrial glandular polyps, and endometrial glandular-fibrous polyps. It has been established that endometrial glandular polyps occur at a younger age compared to atypical endome - trial hyperplasia and glandular-fibrous endometrial polyps. In general, there is a tendency to increase the body mass index in women with HPE. There is no dependence of the type of endometrial hyperplastic processes on growth, body weight, and body mass index. Researching the expression of ER revealed a violation of the receptor status in HPE in the form of their uneven expression in the epithelial and stromal components. An increase in the expression of ER in the endometrial glands compared with the stroma was found to be uneven in intensity and concentration. Violation of the receptor status in hyperplastic processes of the endometrium is characterized by uneven expres - sion of ER in the epithelial and stromal components. Uneven expression of estrogen receptors in the glands and stroma of the endometrium is observed, which does not depend on the anthropometric parameters of the patients. A direct correlation between the expression of estrogen receptors in the epithelium and the stroma of the endome - trium was established. The obtained results can serve as criteria for a differentiated approach to selecting treatment tactics for women with hyperplastic processes of the endometrium.