INTERACTION OF SALMONELLA WITH HOST ORGANISM

M. Boichenko, V. Zverev, E. Volchkova
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引用次数: 3

Abstract

Diseases caused by Salmonella enterica species bacteria remain a healthcare challenge. Salmonella enterica species is divided into typhoid serovars that cause systemic infection and non­ typhoid serovars that most frequently have a course of gastroenteritis with a development of inflam­ matory diarrhea. Both types of salmonella are opportunistic intracellular parasites able to invade and reproduce in both professional and non-professional phagocytes, e.g. M-cells and enterocytes. Invasion of cells and reproduction in them relates to functioning of salmonella pathogenicity island genes that determined synthesis of the third type of secretory system (T3SS). Contrary to the salmonella typhoid group serovars, non-typhoid serovars cause a development of inflammatory diarrhea, and effector molecules of T3SS as well as innate immunity components take part in it.
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沙门氏菌与宿主生物的相互作用
由肠道沙门氏菌引起的疾病仍然是一个卫生保健挑战。肠道沙门氏菌种类分为引起全身感染的伤寒血清型和最常见的肠胃炎伴炎症性腹泻的非伤寒血清型。这两种类型的沙门氏菌都是机会性的细胞内寄生虫,能够在专业和非专业吞噬细胞中侵入和繁殖,例如m细胞和肠细胞。沙门氏菌对细胞的侵袭和繁殖与决定第三型分泌系统(T3SS)合成的致病性岛基因的功能有关。与伤寒沙门氏菌群血清型相反,非伤寒血清型引起炎症性腹泻的发展,T3SS的效应分子以及先天免疫成分参与其中。
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来源期刊
Zhurnal mikrobiologii, epidemiologii, i immunobiologii
Zhurnal mikrobiologii, epidemiologii, i immunobiologii Immunology and Microbiology-Immunology and Microbiology (miscellaneous)
CiteScore
1.40
自引率
0.00%
发文量
51
审稿时长
8 weeks
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