Efficacy of a polylactic acid matrix for the closure of Wagner grade 1 and 2 diabetic foot ulcers: a single-center, prospective randomized trial.

IF 1.4 4区医学 Q3 DERMATOLOGY Wounds : a compendium of clinical research and practice Pub Date : 2023-08-01 DOI:10.25270/wnds/23094

Brock Liden, J. Ramirez-Garcialuna

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Abstract

INTRODUCTION CAMPs are used for treating refractory DFUs where other treatments have failed. PLA is a CAMP that has demonstrated effectiveness in promoting healing in burns and acute wounds. OBJECTIVE A single-center, prospective, randomized controlled trial comparing PLA-guided closure matrices versus collagen dressings was conducted to assess healing of Wagner grades 1 and 2 DFUs. MATERIALS AND METHODS A total of 30 participants were randomized to receive weekly debridement, wound care, and DFU offloading plus either PLA or collagen CAMPs. The primary outcome was the time to achieve full healing, and the secondary outcome was the proportion of ulcers healed at 12 weeks. RESULTS The median time to achieve full healing was 9.3 ± 2.9 weeks in the PLA group versus 14.8 ± 8.1 weeks in the collagen group (P = .021), representing a 44% reduction in the time to heal. Furthermore, by 12 weeks, 80% of the PLA-treated ulcers were healed compared to only 33% in the collagen group (P = .025). CONCLUSION The results of this study show PLA matrices induce a potent healing response that leads to reduced healing time and an increased OR for achieving healing by 12 weeks.

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聚乳酸基质治疗Wagner 1级和2级糖尿病足溃疡的疗效:一项单中心前瞻性随机试验

camp用于治疗其他治疗无效的顽固性dfu。PLA是一种CAMP，在促进烧伤和急性伤口愈合方面已被证明有效。目的:进行一项单中心、前瞻性、随机对照试验，比较pla引导的闭合基质与胶原敷料，以评估Wagner 1级和2级dfu的愈合情况。材料和方法共30名参与者随机接受每周一次的清创、伤口护理和DFU卸载以及PLA或胶原蛋白camp。主要结局是达到完全愈合的时间，次要结局是溃疡在12周内愈合的比例。结果PLA组达到完全愈合的中位时间为9.3±2.9周，而胶原蛋白组为14.8±8.1周(P = 0.021)，愈合时间缩短44%。此外，到12周时，80%的pla治疗的溃疡愈合，而胶原蛋白组只有33%愈合(P = 0.025)。结论:本研究结果表明，聚乳酸基质诱导了一种有效的愈合反应，导致愈合时间缩短，并增加了12周内实现愈合的OR。

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来源期刊

Wounds : a compendium of clinical research and practice 医学-皮肤病学

CiteScore

1.50

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Wounds is the most widely read, peer-reviewed journal focusing on wound care and wound research. The information disseminated to our readers includes valuable research and commentaries on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Our multidisciplinary readership consists of dermatologists, general surgeons, plastic surgeons, vascular surgeons, internal medicine/family practitioners, podiatrists, gerontologists, researchers in industry or academia (PhDs), orthopedic surgeons, infectious disease physicians, nurse practitioners, and physician assistants. These practitioners must be well equipped to deal with a myriad of chronic wound conditions affecting their patients including vascular disease, diabetes, obesity, dermatological disorders, and more. Whether dealing with a traumatic wound, a surgical or non-skin wound, a burn injury, or a diabetic foot ulcer, wound care professionals turn to Wounds for the latest in research and practice in this ever-growing field of medicine.