ModProt: a database for integrating laboratory and literature data about protein post-translational modifications

Y. Kimura, T. Toda, H. Hirano
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引用次数: 2

Abstract

Protein post-translational modifications (PTMs) play crucial roles in regulation of protein function and cell signaling, and abnormalities in protein PTMs are both causes and consequences of disease. Mass spectrometry (MS) is widely used to analyze protein PTMs. In this study, we developed an original database, ModProt (Post-Translational Modification Map of Proteome), to integrate our laboratory data and literature information regarding PTM sites. To develop the ModProt database, we constructed a web-based laboratory information management system (LIMS). This system allows us to administer the ModProt database and to view PTM site maps and corresponding protein information including amino acid sequences, official gene symbols, UniProt accessions/IDs, chromosome number/ positions, and additional description. The ultimate goal of the ModProt database is to achieve PTM-based diagnosis and personalized medicine through detection of abnormal PTMs by comparing PTM site maps in healthy and disease states using the database.
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ModProt:一个整合关于蛋白质翻译后修饰的实验室和文献数据的数据库
蛋白质翻译后修饰(PTMs)在蛋白质功能和细胞信号传导调节中起着至关重要的作用,蛋白质PTMs的异常既是疾病的原因也是疾病的后果。质谱法(MS)广泛用于蛋白质PTMs的分析。在这项研究中,我们开发了一个原始数据库ModProt (Post-Translational Modification Map of Proteome),来整合我们关于PTM位点的实验室数据和文献信息。为了开发ModProt数据库,我们构建了一个基于web的实验室信息管理系统(LIMS)。该系统允许我们管理ModProt数据库,并查看PTM位点图和相应的蛋白质信息,包括氨基酸序列、官方基因符号、UniProt加入/ id、染色体数目/位置和其他描述。ModProt数据库的最终目标是通过比较数据库中健康状态和疾病状态下的PTM位点图,发现异常的PTM,从而实现基于PTM的诊断和个性化医疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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