COMPUTER PREDICTION AND SYNTHESIS OF NEW AZOLES BASED ON N-BENZOYL-N'-(9,10-DIOXO-9,10-DIHYDROANTHRACEN-1-YL)THIOUREAS

Abstract

New thiazole and 1,2,4-triazole derivatives of 9,10-anthraquinone were obtained by the reaction of N-benzoyl-N'-(9,10-dioxo-9,10-dihydroanthracene-1-yl)-thioureas with bromoacetone in the presence of triethylamine and hydrazine hydrate in chloroform, respectively. The PASS computer program was used to predict the biological activity spectra and to determine the most promising biological activities for experimental testing. Thus, it has been shown that the synthesized compounds are a promising class for the creation of substances with a wide range of biological activity. DOI: http://dx.doi.org/10.5755/j01.ct.64.2.6018