AMELIORATIVE EFFECTS OF GALLIC ACID AGAINST OXIDATIVE STRESS IN ERYTHROCYTES INDUCED BY BPA IN MALE ALBINO RATS.

Abstract

Bisphenol A (BPA) is a chemical material that using in polycarbonate plastic that is widely used in daily life items. Several studies showed the adverse effect on the health of erythrocytes in both human and animals, while gallic acid (GA) is a known antioxidant capable of counteracting free radicals. In this study included 4 groups 10 rats each. The first was the control. The second received BPA in drinking water was given ad libitum at dose 40mg/kg.b.w. The third and fourth groups was given BPA by the same dose and by the same route in addition to receive GA in the diet at doses of 50 and 200 mg/kg.b.w, respectively. In erythrocytic hemolysate, the antioxidants: glutathione (GSH), activities of both superoxide dismutase (SOD) and catalase (CAT) were estimated. Also, lipid peroxidation (LPO) and carbonyl protein (CrPr) were determined. The results showed that BPA significantly increased LPO and CrPr and decreased the activities of CAT, SOD and the GSH content. However, the treatments of the BPA-intoxicated rats with GA reversed the erythrocytic oxidative damage and curtailed the decrease in antioxidants. In conclusion, the GA with both doses could attenuate the oxidative damage in erythrocytes of rats-treated with BPA.