{"title":"Hydroamination of Terminal Alkynes by Amines Catalyzed by Copper Heteropoly Salts: A Simple Approach Towards Imine Synthesis","authors":"G. Shanbhag, K. Palraj, S. B. Halligudi","doi":"10.2174/1874095200801020052","DOIUrl":null,"url":null,"abstract":"The hydroamination reaction offers a very attractive route for the synthesis of alkylated amines and their de- rivatives with no byproduct formation. Heterogeneous intermolecular hydroamination reactions of alkynes with aromatic amines using different inexpensive copper salts of hetropolyacid catalysts were investigated. Among heteropoly salts, copper salts of silicotungstic acid showed highest activity. Reactivity of aromatic amines increased with increase in its ba- sicity. Acidity in heterogeneous catalyst can act as promoter in hydroamination of alkynes.","PeriodicalId":23020,"journal":{"name":"The Open Organic Chemistry Journal","volume":"22 1","pages":"52-57"},"PeriodicalIF":0.0000,"publicationDate":"2008-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Organic Chemistry Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874095200801020052","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
The hydroamination reaction offers a very attractive route for the synthesis of alkylated amines and their de- rivatives with no byproduct formation. Heterogeneous intermolecular hydroamination reactions of alkynes with aromatic amines using different inexpensive copper salts of hetropolyacid catalysts were investigated. Among heteropoly salts, copper salts of silicotungstic acid showed highest activity. Reactivity of aromatic amines increased with increase in its ba- sicity. Acidity in heterogeneous catalyst can act as promoter in hydroamination of alkynes.
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