Combined Effects of Ashwagandha, Guggulu and Bauhinia Extracts in the Regulation of Thyroid Function and on Lipid Peroxidation in Mice

Abstract

The combined effects of three different plant extracts (Ashwagandha root, Guggulu gum and Bauhinia bark) on the regulation of thyroid function and on lipid peroxidation have been studied in laboratory mice. Daily administration of these extracts (1.4g kg−1 Ashwagandha, 0.2 g kg−1 Guggulu and 2.5g kg−1 Bauhinia) for 30 days enhanced serum concentrations of both thyroid hormones (thyroxine and triiodothyronine) without altering hepatic lipid peroxidation, indicating that these plant extracts, given in combination, stimulate thyroid function without hepatotoxic effects. The plant extracts also induced an increase in hepatic catalase activity, further suggesting the hepatoprotective nature of the extracts. These plant extracts might be used to formulate a drug for the treatment of hypothyroidism.