Synthesis, Characterization, Antioxidant and Antimicrobial Evaluation of Heterocyclic Dioxaaza Spiro Derivatives

Abstract

The reaction of propane-1, 2-diol, and mercapto ethanol with piperidone yielded a series of novel heterocyclic dioxaaza spiro derivatives of piperidone. IR, Mass, ¹H, ¹³C, HOMOCOSY, and NOESY were used to characterize the synthesized compounds. The compounds were tested for antibacterial, antifungal, and antioxidant activity, as well as drug-likeness in a computer simulation, with respect to bioavailability. The compounds exhibited good antioxidant, antibacterial, and antifungal activity. All of the tested compounds are likely to have sufficient oral bioavailability, as per to in-silico studies, all the parameters were consistent with Lipinski’s five rules. These findings support the view that the synthesized compounds hold promise for drug discovery in the treatment of diseases caused by the pathogens studied.