Advances in the microbiological diagnosis of herpetic retinitis.

IF 1.1 4区 环境科学与生态学 Q4 CHEMISTRY, INORGANIC & NUCLEAR Isotopes in Environmental and Health Studies Pub Date : 2022-09-13 eCollection Date: 2022-01-01 DOI:10.3389/fopht.2022.990240
Julie Gueudry, Bahram Bodaghi
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Abstract

Viral retinitis associated with herpesvirus is one of the most severe forms of uveitis and is a potentially sight-threatening ophthalmologic disease. The prognosis is poor and a rapid and aggressive management is necessary to improve the visual and sometimes vital prognosis of these patients. The treatments used are not without side effects, while many differential diagnoses exist, such as toxoplasmic retinochoroiditis, syphilitic retinitis, endogenous endophthalmitis and intraocular lymphoma. Causatives viruses are herpes simplex virus, varicella-zoster virus, and cytomegalovirus, which require rapid detection in ocular fluid, mainly aqueous humor. However, only a small amount of intraocular fluid is available for analysis. Advances in microbiological diagnostic techniques therefore were key factors in improving the management of these diseases. Historically, the diagnosis was based on immunological tests but more recently advances in molecular biology, in particular polymerase chain reaction, have played a crucial role to obtain a reliable and rapid diagnosis of viral retinitis associated with herpesvirus, as discussed in this review.

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疱疹性视网膜炎微生物诊断的进展。
与疱疹病毒相关的病毒性视网膜炎是葡萄膜炎中最严重的一种,是一种可能危及视力的眼科疾病。这种疾病的预后很差,必须迅速采取积极的治疗措施,以改善患者的视力,有时甚至是生命预后。所使用的治疗方法并非没有副作用,同时还存在许多鉴别诊断,如弓形虫性视网膜炎、梅毒性视网膜炎、内源性眼内炎和眼内淋巴瘤。致病病毒包括单纯疱疹病毒、水痘-带状疱疹病毒和巨细胞病毒,需要在眼液(主要是房水)中快速检测。然而,只有少量眼内液可用于分析。因此,微生物诊断技术的进步是改善这些疾病治疗的关键因素。历史上,诊断是基于免疫学测试,但最近分子生物学,特别是聚合酶链反应的进步在获得与疱疹病毒相关的病毒性视网膜炎的可靠和快速诊断方面发挥了至关重要的作用,本综述将对此进行讨论。
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来源期刊
CiteScore
2.80
自引率
7.70%
发文量
21
审稿时长
3.0 months
期刊介绍: Isotopes in Environmental and Health Studies provides a unique platform for stable isotope studies in geological and life sciences, with emphasis on ecology. The international journal publishes original research papers, review articles, short communications, and book reviews relating to the following topics: -variations in natural isotope abundance (isotope ecology, isotope biochemistry, isotope hydrology, isotope geology) -stable isotope tracer techniques to follow the fate of certain substances in soil, water, plants, animals and in the human body -isotope effects and tracer theory linked with mathematical modelling -isotope measurement methods and equipment with respect to environmental and health research -diagnostic stable isotope application in medicine and in health studies -environmental sources of ionizing radiation and its effects on all living matter
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