Correlation Analysis of 5-HTTLPR Polymorphism and Post-Traumatic Stress Disorder in Li and Han Nationalities of Hainan Province

Abstract

Objective: To analyse the correlation of 5-HTTLPR gene polymorphism and PTSD in Li and Han nationalities of Hainan Province. Methods: Essen trauma inventory (ETI), clinician administered post-traumatic stress disorders scale, (CAPS), tower of Hanoi (TOH), wsiconsin card sorting test (WCST), trail making test (TMT) and wechsler adult intelligence scale revised China (WAIS-RC) were used to investigate patients with PTSD and healthy volunteers (control group). PCR and PPGE were used to detect the polymorphism of 5-HTTLPR gene and analyze its correlation with PTSD. Results: The ETI score, total PTSD score and TMT time of Li nationality patients with PTSD were significantly higher than those of Han nationality patients with PTSD, and the IQ of comprehension and operation in WAIS-RC was significantly lower than that of Han nationality patients with PTSD (P HTTLPR genotype in Li nationality and Han nationality patients with PTSD were significantly higher than those of LL genotype, and the perception, calculation and block diagram in WAIS-RC were significantly lower than those of LL genotype patients (P Conclusions: The SS genotype can increase the risk of PTSD in Li nationality and Han nationality people in Hainan. LL genotype is associated with PTSD of Li and Han nationalities in Hainan, and is an important protective factor for PTSD of Li and Han nationalities in Hainan.