Association of Serum Uric Acid level in Patients with Alzheimer’s Disease

Mohammad Saifullah Ahtesam, M. Habib, Md. Rafiqul Islam, M. R. K. Khan, H. Z. Rahman, A. N. Rizvi, M. Bhuiyan, K. K. Barman, Syeeda Showkat, Md. Monirul Islam, -. Md Raknuzzaman, Md. Fakrul Islam, Imran Sarker, M. Hannan
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Abstract

Background: Alzheimer’s disease is the most common cause of dementia. Uric acid is the end product of purine metabolism in humans and acts as a natural antioxidant, accounting up to 60% of the free radical scavenging activity in human blood to prevent free radicals induced oxidative cell injury. This study aimed to explore the association between serum uric acid level and cognitive impairment of Alzheimer’s disease patients compared to those of the non-demented age and sex matched controls. Methods: This case control study was carried out in the department of neurology, BSMMU, Dhaka. Total 116 patients were enrolled as study population after satisfying inclusion and exclusion criteria. Among them, 58 were grouped as case and rest 58 were control. All blood samples for serum uric acid were measured in the Biochemistry lab, Department of Biochemistry, BSMMU, Dhaka. Results: A signiûcant reduction of serum uric acid levels in the AD group was found compared to those of the control group (4.35±1.59 Vs 6.89±1.68) which was statistically significant (p<0.001). We also found a positive correlation between serum uric acid levels with severity of Alzheimer’s disease (rp = 0.633, P<0.001). Among demographic variables educational qualification was statistically significant (p=0.006) in AD patients. Conclusion: This study showed that oxidative injuries have an important role in the pathogenesis of AD. Higher levels of uric acid are associated with a decreased risk of dementia and better cognitive function later in life. Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 83-88
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阿尔茨海默病患者血清尿酸水平的相关性
背景:阿尔茨海默病是痴呆症最常见的病因。尿酸是人体嘌呤代谢的最终产物,是一种天然的抗氧化剂,占人体血液中自由基清除活性的60%,以防止自由基引起的氧化细胞损伤。本研究旨在探讨血清尿酸水平与阿尔茨海默病患者认知功能障碍之间的关系,并与年龄和性别匹配的非痴呆对照组进行比较。方法:本病例对照研究在达卡BSMMU神经内科进行。在满足纳入和排除标准后,共纳入116例患者作为研究人群。其中58例为病例,其余58例为对照组。所有血清尿酸样本均在达卡BSMMU生物化学系生物化学实验室检测。结果:AD组血清尿酸水平较对照组显著降低(4.35±1.59 Vs 6.89±1.68),差异有统计学意义(p<0.001)。我们还发现血清尿酸水平与阿尔茨海默病的严重程度呈正相关(rp = 0.633, P<0.001)。在人口统计学变量中,AD患者的学历差异有统计学意义(p=0.006)。结论:氧化损伤在AD的发病机制中起重要作用。较高水平的尿酸与老年痴呆症的风险降低和更好的认知功能有关。孟加拉国神经科学杂志2017;Vol. 33 (2): 83-88
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