Daniela Fernandes Ramos, Gilda Guimarães Leitão, Fernanda das Neves Costa, Lisandra Ferreira de Abreu, J. V. Villarreal, Suzana G. Leitão, Salvador Said Fernández, P. Silva
{"title":"Análise da atividade antimicobacteriana de 36 extratos vegetais da Mata Atlântica brasileira","authors":"Daniela Fernandes Ramos, Gilda Guimarães Leitão, Fernanda das Neves Costa, Lisandra Ferreira de Abreu, J. V. Villarreal, Suzana G. Leitão, Salvador Said Fernández, P. Silva","doi":"10.1590/S1516-93322008000400013","DOIUrl":null,"url":null,"abstract":"Thirty-six plant extracts from the brazilian Atlantic Forest were tested for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv and M. kansasii, using the method REMA in seriate concentrations of 100 to 0.20 µg/mL. Among the thirty six extracts tested, five were active against M. tuberculosis, and three of these extracts also showed activity against M. kansasii. Cytotoxicity test with VERO cells was performed with the five extracts active against M. tuberculosis. Only the extract of Peschiera affinis was identified as non-toxic in the concentration of 100µg/mL.","PeriodicalId":21193,"journal":{"name":"Revista Brasileira De Ciencias Farmaceuticas","volume":"23 1","pages":"669-674"},"PeriodicalIF":0.0000,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"23","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Brasileira De Ciencias Farmaceuticas","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/S1516-93322008000400013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 23
Abstract
Thirty-six plant extracts from the brazilian Atlantic Forest were tested for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv and M. kansasii, using the method REMA in seriate concentrations of 100 to 0.20 µg/mL. Among the thirty six extracts tested, five were active against M. tuberculosis, and three of these extracts also showed activity against M. kansasii. Cytotoxicity test with VERO cells was performed with the five extracts active against M. tuberculosis. Only the extract of Peschiera affinis was identified as non-toxic in the concentration of 100µg/mL.
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