EVALUATION OF THE HYPOGLYCAEMIC POTENTIAL OF KIGELIA AFRICANA FRUIT POWDER BEING SOLD IN MALAWIAN RETAIL PHARMACIES

African Journal of Traditional, Complementary and Alternative Medicines Pub Date : 2018-05-30 DOI:10.21010/AJTCAMV15I3.3

F. Lampiao, Samson Kafukiza, Denise Msowoya, Thokozire Phiri, Lina Wyson, L. Alfazema

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引用次数: 3

Abstract

Background: Kigelia africana fruit powder is being sold in Malawian retail pharmacies for the purported purpose of lowering blood sugar in diabetic patients when there is scant data on its hypoglycaemic activity. This study was aimed at evaluating the hypoglycaemic potential of the Kigelia africana fruit powder being sold in Malawian retail pharmacies. Materials and Methods: Hyperglycaemia was induced in rats via intra-peritoneal injection of dexamethasone. Albino rats were randomly allocated into five different groups of eight rats each. Group 1 consisted of non-hyperglycaemic rats receiving no treatment, group 2 consisted of hyperglycaemic rats receiving no treatment, group 3 consisted of hyperglycaemic rats receiving 25mg/kg of metformin, group 4 consisted of hyperglycaemic rats receiving 0.5mL of Kigelia africana fruit powder filtered solution, and group 5 consisted of hyperglycaemic rats receiving 1mL of Kigelia africana fruit powder solution. Results: The Kigelia africana fruit powder filtered solution administered to hyperglycaemic albino rats significantly lowered the sugar level which was comparable to the reduction caused by the pharmacological drug, metformin. Conclusions: Kigelia africana fruit powder has the potential of lowering glucose levels in white albino rats.

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评估在马拉维零售药店出售的非洲桂树果粉的降糖潜力

背景:马拉维零售药店正在销售非洲木果粉，据称其目的是降低糖尿病患者的血糖，但关于其降糖活性的数据很少。本研究的目的是评估在马拉维零售药店销售的非洲木果粉的降糖潜力。材料与方法:腹腔注射地塞米松诱导大鼠高血糖。将白化大鼠随机分为5组，每组8只。1组为未处理的非高血糖大鼠，2组为未处理的高血糖大鼠，3组为高血糖大鼠，给予25mg/kg二甲双胍，4组为高血糖大鼠，给予0.5mL非洲桂子果粉过滤液，5组为高血糖大鼠，给予1mL非洲桂子果粉溶液。结果:高血糖化白化病大鼠服用非洲桂子果粉过滤液后，血糖水平明显降低，其作用与药理药物二甲双胍相当。结论:非洲桂子粉具有降低白化大鼠血糖水平的作用。

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来源期刊

African Journal of Traditional, Complementary and Alternative Medicines 医学-全科医学与补充医学

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The “African Journal of Traditional, Complementary and Alternative Medicines (AJTCAM)” is a peer-reviewed, multidisciplinary, international, scientific Open Access Journal that provides publication of articles on phytomedicines, ethnomedicines and veterinary ethnomedicines. The journal is published by a Non-Governmental Organization (NGO) known as “African Traditional Herbal Medicine Supporters Initiative (ATHMSI)”. The Journal welcomes submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published approximately two-to-three months after acceptance