Antihyperglycemic activity of Madhuca longifolia in alloxan -induced diabetic rats

Abstract

Madhuca longifolia commonly known as theButter nut treeis used traditionally in the Indian folk medicine for the treatment of diabetes mellitus. The hydroethanolic extract of the leaves of Madhuca longifolia was administered orally to alloxaninduced diabetic rats and investigated for its antidiabetic properties. Administration of 150 mg/kg and 300 mg/kg extract (once a day, for thirty consecutive days) significantly lowered blood glucose levels. Furthermore, the activity of glucose-6-phosphate dehydrogenase, serum triglycerides, HDL and total cholesterol levels showed marked improvement which indicates that the hydroethanolic extract possesses antihyperglycemic activity.