The Common Marmoset-Biomedical Research Animal Model Applications and Common Spontaneous Diseases.

IF 0.6 4区哲学 Q2 HISTORY & PHILOSOPHY OF SCIENCE Theology and Science Pub Date : 2022-07-01 Epub Date: 2022-05-10 DOI:10.1177/01926233221095449

Hyo-Jeong Han, Sarah J Powers, Kathleen L Gabrielson

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Abstract

Marmosets are becoming more utilized in biomedical research due to multiple advantages including (1) a nonhuman primate of a smaller size with less cost for housing, (2) physiologic similarities to humans, (3) translatable hepatic metabolism, (4) higher numbers of litters per year, (5) genome is sequenced, molecular reagents are available, (6) immunologically similar to humans, (7) transgenic marmosets with germline transmission have been produced, and (8) are naturally occurring hematopoietic chimeras. With more use of marmosets, disease surveillance over a wide range of ages of marmosets has been performed. This has led to a better understanding of the disease management of spontaneous diseases that can occur in colonies. Knowledge of clinical signs and histologic lesions can assist in maximizing the colony's health, allowing for improved outcomes in translational studies within biomedical research. Here, we describe some basic husbandry, biology, common spontaneous diseases, and animal model applications for the common marmoset in biomedical research.

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普通狨猴--生物医学研究动物模型应用和常见自发性疾病。

狨猴在生物医学研究中的应用越来越广泛，这是因为狨猴具有多种优势，包括：（1）体型较小，饲养成本较低；（2）生理结构与人类相似；（3）可转化的肝脏代谢；（4）每年产仔数较多；（5）基因组已被测序，可获得分子试剂；（6）免疫学与人类相似；（7）具有种系的转基因狨猴、(4)每年产仔数较多；(5)基因组已测序，可获得分子试剂；(6)免疫学上与人类相似；(7)已生产出具有种系传播的转基因狨猴；(8)是自然发生的造血嵌合体。随着狨猴使用的增多，对不同年龄段的狨猴进行了疾病监测。这使人们对狨猴群落中可能发生的自发性疾病的疾病管理有了更好的了解。对临床症状和组织学病变的了解有助于最大限度地提高狨猴群的健康水平，从而提高生物医学研究中转化研究的成果。在此，我们将介绍普通狨猴在生物医学研究中的一些基本饲养方法、生物学、常见自发性疾病和动物模型应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Theology and Science Arts and Humanities-History and Philosophy of Science

CiteScore

0.80

自引率

16.70%

发文量

期刊介绍： Membership of The Center for Theology and the Natural Sciences (CTNS) includes a subscription to Theology and Science . To become a member, please click here to view the current options. The primary editorial goal of Theology and Science is to publish critically reviewed articles that promote the creative mutual interaction between the natural sciences and theology. While the journal assumes the integrity of each domain, its primary aim is to explore this interaction in terms of the implications of the natural sciences for constructive research in philosophical and systematic theology, the philosophical and theological elements within and underlying theoretical research in the natural sciences, and the relations and interactions between theological and scientific methodologies. The secondary editorial goal is to monitor and critically assess debates and controversies arising in the broader field of science and religion. Thus, Theology and Science will investigate, analyze, and report on issues as they arise with the intention of prompting further academic discussion of them.This editorial policy is formulated with the guiding confidence that a serious dialogue between science and theology will lead to a variety of new and progressive research programs, and that these in turn will yield new insights, deeper understanding, and new knowledge at the frontiers of science and religion.