Neuronal Activity and its Impact on Neuronal Growth

Abstract

Myelination is one of the most important aspect of membrane remodeling, hence it is very much essential to understand the factors that can aid in remyelination once the myelin layer gets reduced or is lost due to several physiological factors. Studies have shown that the activities taking place within the nervous system itself can aid in remyelination. The current study is based on understanding the role action potential play in aiding in remyelination of the nerve fiber which would not only help in regaining the strength of the signal and also for the faster propagation of the impulse thus addressing several neurological issues arising due to myelin degradation. The idea is to develop an appropriate mathematical model to study the effects of the action potential in remyelination which will be computationally viable and to understand its role in neuronal growth. The findings of this study suggest that variation in the rate at which the membrane potential changes can have a significant impact on neuronal growth and therefore the issues arising out of myelin degradation such as multiple scheloris could be addressed.