Lung cancer and combined pulmonary fibrosis and emphysema with anti-ARS antibody

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2022-05-22 DOI:10.2478/rjim-2022-0008
Riho Tanimura, Kengo Nishino, Ryosuke Iwade, Ryo Abe, S. Okauchi, Y. Sasatani, H. Satoh
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Abstract

Abstract A 59-year-old man who had smoked for 23 pack-years was admitted to our hospital because of two-month history of back pain. The chest computed tomography scan demonstrated combined pulmonary fibrosis and emphysema (CPFE) and an irregular shaped nodule in the left lower lobe of the lung. A biopsy obtained from samples from subcarinal lymph nodes revealed non-small cell lung cancer. Anti-aminoacyl-tRNA synthetase (ARS) antibody was elevated up to 166 U/mL, although he had no symptoms suggestive connective tissue diseases. It is well known that most of CPFE patients are current or former heavy smokers, and some researchers described the relationship between CPFE and connective tissue diseases. To our best knowledge, this was the first report of lung cancer in patient with anti-ARS antibody-positive CPFE. In some anti-ARS antibody-positive patients, smoking might have a relationship with development of CPFE and lung cancer.
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肺癌及合并肺纤维化、肺气肿伴抗ars抗体
摘要一位吸烟23包年的59岁男性因2个月的背痛病史入院。胸部计算机断层扫描显示合并肺纤维化和肺气肿(CPFE)和左肺下叶不规则形状的结节。从隆突下淋巴结样本中获得的活检显示非小细胞肺癌。抗氨基酰基trna合成酶(ARS)抗体升高至166 U/mL,尽管他没有结缔组织疾病的症状。众所周知,大多数CPFE患者是当前或曾经的重度吸烟者,一些研究人员描述了CPFE与结缔组织疾病之间的关系。据我们所知,这是首例抗ars抗体阳性CPFE患者发生肺癌的报道。在一些抗ars抗体阳性的患者中,吸烟可能与CPFE和肺癌的发生有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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