Insights on Bioactive Peptide-loaded Nanoformulations

Venkateshwaran Krishnaswami, B. Natarajan, Saravanakumar Arthnari, Jeseeta Suresh, Nirmal Aranvindaraj
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Abstract

In order to tackle multifactorial illnesses, the importance of bioactive peptides in nano drug delivery systems is emphasised. Multifactorial diseases are primarily brought on by protein misfolding. Therefore, pharmaceutical formulations are recommended to deliver a successful treatment. Difficulties hinder its application in delivering raw peptides with poor bioavailability, absorption, and circulation time, making it a difficult assignment for researchers. Recently, bioactive peptides have become increasingly important in therapy. In addition, several bioactive proteins have poor absorption characteristics in the GIT. These issues can be resolved by creating nano-based peptide-based delivery systems that encapsulate, retain, protect, and transport bioactive peptides. The focus of the proposed review paper is to provide an overview of peptides, commercialization concerns, and their related attempts to develop into novel peptide-based nanoformulations.
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生物活性肽负载纳米制剂的见解
为了解决多因素疾病,强调了生物活性肽在纳米给药系统中的重要性。多因子疾病主要是由蛋白质错误折叠引起的。因此,建议药物配方提供成功的治疗。困难阻碍了它在递送生物利用度差、吸收和循环时间差的生肽方面的应用,使其成为研究人员的困难任务。近年来,生物活性肽在治疗中发挥着越来越重要的作用。此外,一些生物活性蛋白在GIT中的吸收特性较差。这些问题可以通过创建基于纳米肽的递送系统来解决,这些系统可以封装、保留、保护和运输生物活性肽。这篇综述的重点是概述肽、商业化问题,以及开发新型肽基纳米制剂的相关尝试。
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